Hydrophilic vitamins or water-soluble vitamins are an important class of active ingredients present in various food supplements formulations in the form of capsules, tablets, sachets, syrups etc. Water-soluble vitamins usually are found in complex multivitamin/multimineral formulations in a wide concentration range: from μg to mg per dosage. Considering water-soluble vitamins sensitivity to heat, light, pH variations, component interactions and other factors that may contribute to the loss of stability it is important to follow their stability and monitor the labelled content during product development and declared shelf-life by using validated analytical methods.
The amount of the water-soluble vitamins in food supplements have to be controlled and quantified with selective and sensitive analytical methods in order to ensure quality and safe product. Routine analysis of vitamins is quite challenging due to the complexity of the matrices and the unstable nature of the active ingredients.
In our laboratory, we can assist you in designing and conducting stability studies for multivitamin/multimineral supplements, as well as sample analysis and development of analytical methods specifically for your complex products.
You can order also control of the active ingredient content in raw materials and product specification to ensure quality in the supply chain for early development to commercialisation.
We are experts in the analysis of water-soluble vitamins in various formulations and dosage forms:
– Vitamin B1: thiamine hydrochloride, thiamine mononitrate
– Vitamin B2: riboflavin, riboflavin-5’-phosphate
– Vitamin B3: nicotinic acid, nicotinamide
– Vitamin B5: pantothenic acid, calcium pantothenate
– Vitamin B6: pyridoxine hydrochloride, pyridoxal 5’ phosphate (PLP), pyridoxamine
– Vitamin B7: biotin
– Vitamin B9: folic acid, 5-methyltetrahydrofolate
– Vitamin B12: cyanocobalamin, methylcobalamin, hydroxycobalamin and 5-deoxyadenosylcobalamin
– Vitamin C: L-ascorbic acid, ascorbyl palmitate, calcium-L-ascorbate
Content analysis of water-soluble vitamins is performed using optimised sample preparation methods and HPLC techniques with various detection methods, following industry standards and analytical guidelines for method development and validation.
For more information on water-soluble vitamin analysis contact us and receive your informational quote for analysis of your products.